Lipidic Nanostructures as carriers for controlled drug delivery
M. Trif, A. Roseanu, J. M. Brewer, J. H. Brock

Abstract. This study focuses on the possible therapeutic utility of lipidic nanostructures in the local treatment of inflammatory disorders, such as the rheumatoid arthritis. Our purpose was to design a delivery system for an anti-inflammatory glycoprotein, human lactoferrin (hLf), using liposomes as carriers to overcome the limitations of conventional therapies and to investigate its in vivo effectiveness.

Abbreviations: cholesterol (Chol); cholesterylhemisuccinate (CHEMS); dioleoylphosphatidylethanolamine (DOPE); dipalmitoylphosphatidylethanolamine (DPPE); human lactoferrin (hLf); phosphatidylcholine (PC); phosphatidylserine (PS); stearylamine (SA); rheumatoid arthritis (RA).